{ "_id": "6a1f3840b401979e73428dcd", "Package": "rPBK", "Title": "Inference and Prediction of Generic Physiologically-Based\nKinetic Models", "Version": "0.2.5", "Authors@R": "c(\nperson(\"Virgile\", \"Baudrot\", role = c(\"aut\",\"cre\"), email = \"virgile.baudrot@qonfluens.com\"),\nperson(\"Sandrine\", \"Charles\", role = \"aut\"),\nperson(\"Christelle\", \"Lopes\", role = \"aut\"),\nperson(\"Ophélia\", \"Gestin\", role = \"ctb\"),\nperson(\"Dominique\", \"Lamonica\", role = \"ctb\"),\nperson(\"Aurélie\", \"Siberchicot\", role = \"ctb\")\n)", "BugReports": "https://gitlab.in2p3.fr/mosaic-software/rPBK/-/issues", "URL": "https://gitlab.in2p3.fr/mosaic-software/rPBK/", "Description": "Fit and simulate any kind of physiologically-based kinetic\n('PBK') models whatever the number of compartments. Moreover,\nit allows to account for any link between pairs of\ncompartments, as well as any link of each of the compartments\nwith the external medium. Such generic PBK models have today\napplications in pharmacology (PBPK models) to describe drug\neffects, in toxicology and ecotoxicology (PBTK models) to\ndescribe chemical substance effects. In case of exposure to a\nparent compound (drug or chemical) the 'rPBK' package allows to\nconsider metabolites, whatever their number and their phase (I,\nII, ...). Last but not least, package 'rPBK' can also be used\nfor dynamic flux balance analysis (dFBA) to deal with metabolic\nnetworks. See also Charles et al. 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